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Biotin / Finasteride / Minoxidil Capsules

Biotin / Finasteride / Minoxidil Capsules are formulated to address various health and cosmetic needs with their distinct functions and benefits. Each capsule combines three active ingredients, with dosages available in 5 mg / 2.5 mg / 2.5 mg and 5 mg / 2.5 mg / 0.25 mg strengths, tailored to meet specific health requirements. Biotin, a B vitamin essential for carbohydrate, fat, and amino acid metabolism, supports metabolic processes and is commonly used for hair and nail health. Finasteride, a 5-alpha reductase inhibitor, is utilized to manage benign prostatic hyperplasia (BPH) and androgenetic alopecia by reducing DHT levels. Minoxidil serves both as an oral antihypertensive and a topical treatment for hair loss, promoting hair regrowth in affected individuals.

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About Biotin / Finasteride / Minoxidil Capsules

Biotin

Function: Biotin, also known as vitamin H, is a B vitamin crucial for carbohydrate, fat, and amino acid metabolism. It acts as a cofactor for enzymes involved in these processes and plays a role in gene regulation and cell signaling.

  • Sources: Biotin is naturally found in various foods, including liver, kidney, muscle, eggs, fish, seeds, and nuts.

  • Uses: Biotin supplements are promoted for treating hair and nail problems, biotinidase deficiency, and certain conditions like cradle cap, diabetes, peripheral neuropathy, and high cholesterol. It is also used in situations where biotin deficiency is more likely, such as during pregnancy or dialysis.

  • Cosmetic Use: Biotin is commonly found in cosmetics, and radiolabeled biotin is used in cancer therapy.

Finasteride

Function: Finasteride is a 5-alpha reductase inhibitor, primarily used to treat benign prostatic hyperplasia (BPH) and male pattern baldness (androgenetic alopecia).

  • BPH Treatment: Finasteride reduces prostate size and increases urine flow in men with BPH. It also lowers serum PSA concentrations, which can complicate prostate cancer detection.

  • Prostate Cancer Risk: While finasteride reduces the overall risk of prostate cancer, it has been associated with an increased risk of high-grade prostate cancer.

  • Hair Loss Treatment: Finasteride is effective for mild to moderate hair loss on the vertex and mid-scalp area but is not established for bitemporal recession. It was approved by the FDA for BPH in 1992 and for male pattern baldness in 1997.

  • Investigational Use: Finasteride has also been explored as a treatment for hirsutism.

Minoxidil

Function: Minoxidil is used as an oral antihypertensive agent and as a topical treatment for alopecia (hair loss).

  • Topical Use: Topical minoxidil is effective in promoting hair growth in about 30% of men and 60% of women with hereditary hair loss. It can also halt the progression of alopecia.

  • Oral Use: Oral minoxidil is reserved for severe, drug-resistant hypertension due to its potency and potential side effects.

  • FDA Approvals: The topical form was approved in 1988 for alopecia, with over-the-counter use approved in 1996 for men and 1997 for women. A 5% topical solution, which promotes faster and more significant hair regrowth, was approved in 1997, and minoxidil foam was approved for men in 2006.

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Comprehensive Formulation

Each capsule combines biotin, finasteride, and minoxidil in specific dosages to address multiple health concerns, including hair loss, prostate health, and metabolic function, offering a multifaceted approach to wellness.

Targeted Hair Health Support

The combination of biotin and minoxidil promotes hair growth and reduces hair loss, benefiting individuals with hereditary hair loss and those seeking to enhance overall hair health.

Prostate and Metabolic Benefits

Finasteride helps manage benign prostatic hyperplasia (BPH) and reduces DHT levels, while biotin supports carbohydrate, fat, and amino acid metabolism, contributing to a balanced metabolic profile.

Product Overview

5/5

Dosage Strengths

  • Biotin / Finasteride / Minoxidil Capsule (Each) 5 mg / 2.5 mg / 2.5 mg | 5 mg / 2.5 mg / 0.25 mg
Promotes Hair Growth
1
Enhances Hair Health
2
Strengthens Hair Follicles
3

More Details About Product

Biotin

  • Role in Metabolism: Biotin is a water-soluble B vitamin crucial for the metabolism of carbohydrates, fats, and amino acids. It acts as a cofactor for five essential carboxylases involved in these metabolic processes.

  • Absorption and Utilization: Biotin is protein-bound in foods and released through proteolysis in the gastrointestinal tract. It is absorbed in the small intestine after being freed from proteins by biotinidase.

  • Functions: Biotin supports fatty acid synthesis, glucose production, and amino acid metabolism, making it vital for maintaining metabolic homeostasis. It is also involved in histone modifications, gene regulation, and cell signaling.

Finasteride

  • Inhibition of DHT: Finasteride is a synthetic 4-aza analog of testosterone that specifically inhibits type II 5-alpha-reductase, the enzyme responsible for converting testosterone into dihydrotestosterone (DHT), a potent androgen.

  • Impact on BPH and Hair Loss: By reducing DHT levels, finasteride helps decrease prostate size in benign prostatic hyperplasia (BPH) and prevents the miniaturization of hair follicles in androgenetic alopecia.

  • Selective Action: Finasteride primarily reduces DHT without significantly affecting other hormones such as cortisol, estradiol, or thyroid hormones, and it does not interfere with the hypothalamic-pituitary-testicular axis.

Minoxidil

  • Vasodilatory Effects: Minoxidil acts as a vasodilator by directly relaxing arterial smooth muscle, leading to reduced peripheral resistance and blood pressure. It increases cyclic adenosine monophosphate (cAMP) levels, which contributes to smooth muscle relaxation.

  • Compensatory Responses: The vasodilation triggers sympathetic responses, including increased heart rate and fluid retention, often requiring the concurrent use of beta-blockers and diuretics in hypertensive patients.

  • Hair Growth Mechanism: While the exact mechanism is not fully understood, minoxidil appears to promote hair growth by shortening the latent period of the hair cycle and possibly affecting calcium’s role in hair follicle activity. It may also alter androgen metabolism in the scalp, potentially enhancing hair growth in balding areas. Minoxidil is most effective on suboptimal hair follicles and does not stimulate the formation of new follicles.

Biotin

  • Lab Test Interference: High doses of biotin (10-300 mg/day) can interfere with lab tests that use biotin-streptavidin technology, leading to inaccurate results. This interference can cause falsely high or low readings, particularly in tests for cardiovascular diagnostics and hormone levels. One reported case involved a patient who died after a falsely low troponin result due to biotin interference. Health care providers should inquire about biotin supplementation and inform the lab conducting tests to avoid diagnostic errors.

  • Pregnancy and Breastfeeding: Biotin is safe during pregnancy and breastfeeding within the recommended adequate intake (AI) levels. Supplementation beyond dietary intake is generally unnecessary unless a deficiency is diagnosed.

Finasteride

  • Pregnancy: Finasteride is contraindicated in women of childbearing potential due to the risk of fetal harm, particularly the development of abnormalities in the external genitalia of male fetuses. Pregnant women should avoid handling crushed or broken tablets to prevent exposure.

  • Breastfeeding: The use of finasteride is not recommended during breastfeeding as its excretion in human milk is unknown.

  • Pediatric Use: Finasteride is not approved for use in children or adolescents under 18 years of age, as safety and effectiveness have not been established.

  • Hepatic Disease: Use caution in patients with hepatic disease, as finasteride is metabolized in the liver. There is limited data on adverse effects or drug accumulation in patients with liver impairment.

  • Prostate Cancer Risk: Finasteride lowers serum PSA levels, which may mask the detection of prostate cancer. The FDA has warned of a potential increased risk of high-grade prostate cancer with finasteride use. Clinicians should consider this risk when prescribing and monitor patients for prostate cancer.

  • Blood Donation: Men taking finasteride should avoid donating blood to prevent the risk of exposing pregnant females to the drug.

  • Fertility Effects: Finasteride may affect semen characteristics, including sperm count, motility, and volume, potentially impacting male fertility. These effects may be reversible after discontinuation.

Minoxidil

  • Cardiac Lesions: Minoxidil has been associated with cardiac lesions in animals, and these effects are more likely in patients with conditions like renal dysfunction, connective tissue disease, or congestive heart failure (CHF).

  • Cardiovascular Disease: Minoxidil is relatively contraindicated in patients with cardiovascular conditions such as angina, coronary artery disease, or recent myocardial infarction, due to the risk of exacerbating these conditions through reflex tachycardia and hypotension. Pericardial effusion and cardiac tamponade are also potential risks.

  • Renal Disease: Use caution in patients with renal disease, as minoxidil can increase pulmonary artery pressure. It is relatively contraindicated in patients with severe renal failure (CrCl < 10 ml/min).

  • Pheochromocytoma: Minoxidil is contraindicated in patients with pheochromocytoma, as its hypotensive effects could trigger catecholamine secretion.

  • Topical Use: Systemic effects from topical minoxidil are rare but possible if overused or applied to areas with skin damage, such as abrasions or psoriasis. Elderly patients should use caution, particularly with systemic minoxidil, due to the higher risk of adverse effects related to decreased organ function and comorbidities.

Biotin

  • General: Biotin is generally well-tolerated, with very few reported adverse effects, even at high doses.

  • Rare Case: There is one reported case of life-threatening eosinophilic pleuro-pericardial effusion in an elderly woman who took a combination of 10 mg/day of biotin and 300 mg/day of pantothenic acid for two months.

Finasteride

  • Sexual Function: The most frequently reported adverse reactions are related to sexual function, including:
    • Impotence (Erectile Dysfunction)
    • Decreased Libido
    • Decreased Ejaculate Volume
    • Ejaculation Dysfunction
    • Orgasm Disorders
    • Continued Sexual Dysfunction: Some patients report continued sexual dysfunction even after discontinuing the drug.

  • Gynecomastia (Breast Enlargement):
    • Finasteride has been associated with gynecomastia, with cases reported ranging from 14 days to 2.5 years after starting the drug.
    • Some patients experienced new malignancies, such as primary intraductal breast cancer, after developing gynecomastia.

  • Male Breast Cancer: There have been post-marketing reports of male breast cancer associated with finasteride.

  • Psychological Effects:
    • Depression and Testicular Pain have been reported, persisting even after discontinuation of the drug.
    • Hypersensitivity Reactions: These include pruritus, urticaria, and angioedema (swelling of the lips, tongue, throat, and face).

  • Effects on Fertility:
    • Finasteride may cause a reduction in sperm count, motility, and semen volume, potentially affecting male fertility.
    • One study reported a significant decrease in sperm count (-34.3%) after 26 weeks of treatment, with partial recovery observed at follow-up.

  • Teratogenicity: Finasteride and other 5-alpha-reductase inhibitors may cause teratogenic effects, particularly abnormalities in the external genitalia of male fetuses.

Minoxidil

  • Dermatological Reactions (Topical Use): Increased incidence of local dermatological effects such as contact dermatitis, burning, pruritus, erythema, or xerosis.

  • Systemic Effects (Oral Use):
    • Fluid Retention: Leads to peripheral edema, ascites, and occasionally refractory fluid retention requiring discontinuation of therapy.
    • Reflex Tachycardia: May occur, with potential exacerbation of angina due to increased myocardial oxygen demand.
    • Laboratory Changes: Transient decreases in hematocrit, hemoglobin, and erythrocyte count, as well as increases in serum creatinine and BUN, have been observed.
    • Hypertrichosis: Unwanted hair growth in areas such as the temples, eyebrows, and scalp, which is reversible after discontinuation.
    • Serious Skin Reactions: Rare occurrences of bullous rash and Stevens-Johnson syndrome.
    • Gastrointestinal Effects: Nausea and vomiting have been associated with orally administered minoxidil.
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond-use date. Do not flush unused medications or pour down a sink or drain.
Store this medication in its original container at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

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